brazil
overview
The Regional Prospective Observational Research in Tuberculosis (RePORT) Brazil network was established in August, 2013 with funding from the Departamento de Ciência e Tecnologia (DECIT) – Secretaria de Ciência e Tecnologia (SCTIE) of the Ministry of Health of Brazil, and the National Institutes of Health of the United States.
RePORT Brazil is a joint venture among the Departamento de Ciência e Tecnologia/Ministério da Saude (DECIT), the U.S. Office of AIDS Research and NIAID, co-funding a team of Brazil- and U.S.-based investigators to enroll people with active and latent TB in Brazil. Three sites in Rio de Janeiro, one in Manaus, and one in Salvador were selected to enroll up to 1,200 active TB cases and 2,700 close contacts of those TB cases (RePORT-Brazil phase 1). During phase 2 of enrollment (from 2021 to 2026), our plan is to enroll 1,000 new TB cases and 2,000 close contacts.
The consortium sites also represent a diverse population and are enrolling into a single protocol, which is harmonized with the RePORT International Common Protocol. Vanderbilt University Medical Center is the U.S.-based academic partner working with RePORT Brazil. RePORT Brazil is led by a scientific and steering committee composed of researchers and members of NIH and Brazilian Ministry of Health, who provide leadership, governance, and guidance to the consortium.
1
Rio de Janeiro SITES
Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz
Secretaria Municipal de Saúde do Rio de Janeiro e Clínica da Família Rinaldo Delamare, Rocinha
Centro Municipal de Saúde de Duque de Caxias and UFRJ
2
Manaus
Fundação de Medicina Tropical
3
Salvador
Instituto Brasileiro para Investigação da Tuberculose
4
biorepository
José Silveira Foundation
5
cood center
Vanderbilt University Medical Center
objective
The primary objective of RePORT Brazil is to describe the clinical outcomes of TB treatment in Brazil, and the occurrence of M. tuberculosis infection and TB disease among close contacts of those TB source cases.
1
biorepository & database
Creation and maintenance of a biorepository of clinical specimens and a database of well-characterized clinical endpoints for the TB cases and their close contacts
2
scientific agenda
Development of a scientific agenda that will utilize this specimen and data repository to improve understanding of TB pathogenesis
3
Lab & clinical research
Develop a TB laboratory and clinical research infrastructure in Brazil
administration
RePORT Brazil is led by a scientific and steering committee composed of researchers and members of NIH and Brazilian Ministry of Health, who provide leadership, governance, and guidance to the consortium.
Bruno Andrade
PI & BIOREPOSITORY
Salvador
Timothy Sterling
PI, VUMC
Vanderbilt University Medical Center, USA
Valeria Rolla
Co-investigator
Rio de Janeiro
Stephany Norah Duda
VUMC
Vanderbilt University Medical Center, USA
funding
RePORT Brazil acknowledges funding from National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), CRDF Global, Departamento de Ciencia e Tecnologia (DECIT) – Secretaria de Ciencia e Tecnologia (SCTIE) of the Ministry of Health of Brazil.